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Index > Protein center > Nme1(Gene name) > Mouse
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  • Nme1 (Gene name),
  • Nucleoside diphosphate kinase A (Protein name ),  NDKA_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Nme1(Nm23);
    Protein name:
    Nucleoside diphosphate kinase A(NDK A;NDP kinase A);
    Alternative:
    NDPK-A;Metastasis inhibition factor NM23;nm23-M1;Tumor metastatic process-associated protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with SET and PRUNE.
    Function:
    Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    152
    Sequence:
    50:
    MANSERTFIA | IKPDGVQRGL | VGEIIKRFEQ | KGFRLVGLKF | LQASEDLLKE | 
    100:
    HYTDLKDRPF | FTGLVKYMHS | GPVVAMVWEG | LNVVKTGRVM | LGETNPADSK | 
    150:
    PGTIRGDFCI | QVGRNIIHGS | DSVKSAEKEI | SLWFQPEELV | EYKSCAQNWI | 
    152:
    YE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    KEGG:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse NDK A
    MSDS:
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    ELISA Kit for Mouse NDK A
    Cat.:
    E14300h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse NDK A
    MSDS:
    Please sign in first.
    ELISA Kit for Mouse NDK A
    Cat.:
    E14300m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse NDK A
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse NDK A
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse NDK A
    Cat.:
    U14300m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse NDK A
    Cat.:
    U14300h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse NDK A
    Polyclonal Antibody for Mouse NDK A
    Polyclonal Antibody for Mouse NDK A
    Polyclonal Antibody for Mouse NDK A
    Monoclonal Antibody for Mouse NDK A
    Monoclonal Antibody for Mouse NDK A
    Monoclonal Antibody for Mouse NDK A
    Monoclonal Antibody for Mouse NDK A
    Protein for Mouse NDK A
    Protein for Mouse NDK A
    Protein for Mouse NDK A
    Protein for Mouse NDK A

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    Precision
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    Linearity
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    References
    1. 1.
      "Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development."
      Rosengard A.M. , Krutzsch H.C. , Shearn A. , Biggs J.R. , Barker E. , Margulies I.M.K. , King C.R. , Liotta L.A. , Steeg P.S.
      Nature342:177-180(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Evidence for a novel gene associated with low tumor metastatic potential."
      Steeg P.S. , Bevilacqua G. , Kopper L. , Thorgeirsson U.P. , Talmadge J.E. , Liotta L.A. , Sobel M.E.
      J. Natl. Cancer Inst.80:200-204(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells."
      Leone A. , Flatow U. , King C.R. , Sandeen M.A. , Margulies I.M. , Liotta L.A. , Steeg P.S.
      Cell65:25-35(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      Dabernat S. , Masse K. , Daniel J.Y.
      Submitted (1997-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: 129/Sv.
    5. 5.
      Gervasi F. , Fanciulli M. , Lombardi D.
      Submitted (1997-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Swiss Webster / NIH.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary gland.
    7. 7.
      Lubec G. , Klug S. , Kang S.U.
      Submitted (2007-04) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 7-26; 67-85; 89-124 AND 129-143;IDENTIFICATION BY MASS SPECTROMETRY
      strain: C57BL/6.
      tissue: Brain.
      tissue: Hippocampus.
    8. 8.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-124;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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